The Pre-registration of Research Projects is sponsored by OpenCiencia to solve the crisis of replicability in Science and improve the quality of research products. Our approach is to carry out a second order change in Science mentoring the researcher from the beginning until the end of the research project and promoting the replication of studies. Guided by high qualified experts, researchers pre-register their projects being mentored on the topic. Likewise, experts timely correct issues in the research proposal, project and product. The Pre-registration of Research Projects operates under the Open Access Movement.